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机械循环支持装置对白细胞表型和功能的影响

Zhuo Li¹, Zhenling Wei¹, Wangwang Su¹

¹Artificial Organ Technology Lab, Bio-manufacturing Engineering Centre, School of Mechanical and Electrical Engineering, Soochow University, NO. 8 Jixue Road, Suzhou, Jiangsu, 215006, China.

Cardiovascular engineering and technology

|April 18, 2025

概括

机械循环支持器械 (MCSDs) 可以损害白细胞 (WBCs),损害免疫功能并增加并发症风险. 综合性评估需要评估WBC功能和细胞计数.

科学领域:

生物医学工程生物医学工程
血液学血液学血液学
免疫学免疫学免疫学

背景情况:

机械循环支持装置 (MCSD) 对末期心力衰竭 (HF) 至关重要.
经过外来表面和非生理剪切应力 (NPSS),MCSDs可以引起血细胞损伤.
由于MCSD造成的白细胞 (WBC) 损伤与红细胞 (RBC) 和血小板 (PLT) 相比,研究不足.

研究的目的:

调查MCSDs对WBCs的影响.
突出WBC损害评估在机械循环支持中的重要性.
审查白细胞损伤机制,临床相关性和调查方法.

主要方法:

审查由MCSD因素引起的WBC表型和功能损伤.
分析白细胞损伤与临床并发症之间的关系.
实验室血液切割装置 (BSD) 和白细胞损伤检测方法的比较综述.

主要成果:

NPSS和生物材料激活白细胞,降低其功能,并促进亲炎性/亲血栓性微粒的释放.
白血球激活增加了炎症和血栓性并发症的风险.
试验室BSD和流细胞计等方法用于评估WBC活力和功能障碍.

结论:

在MCSD中,白血球可以遭受NPSS的功能失败和次致命损伤,即使形态正常.
测量WBC功能能力和细胞数量的综合方法可以更彻底地评估MCSD的影响.
了解白血球损伤对于减轻机械循环支持中的不良事件至关重要.

关键词:

检测方法检测方法在体外切割血液设备.炎症炎症是一种炎症.白血球受损的损伤.剪切压力压力是什么

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