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丹麦的rimegepant采用:基于登记册的研究吸收,处方模式和发起者特征
Lanfranco Pellesi1, Thien Phu Do2,3,4, Martin Thomsen Ernst5
1Clinical Pharmacology, Pharmacy and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark. lpellesi@health.sdu.dk.
The journal of headache and pain
|April 18, 2025
概括
作为偏头痛的CGRP受体对手的Rimegepant在丹麦迅速普及,特别是在之前使用过三类药物的女性中. 然而,高停药率表明,持续的治疗坚持存在挑战.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 里梅格潘特是第一种口服的素基因相关 (CGRP) 受体对抗剂,已被批准用于急性和预防性偏头痛治疗.
- 这项研究调查了丹麦的rimegepant的实际使用模式.
研究的目的:
- 为了研究rimegepant在市场推出后在丹麦的吸收和使用趋势.
- 评估rimegepant使用者的人口和临床特征.
- 评估治疗的坚持和对同时服用药物的影响.
主要方法:
- 分析2022年10月至2024年12月的全国医疗保健登记数据.
- 追踪rimegepant处方,用户人口统计和临床病史.
- 评估时间趋势,坚持和同时使用其他偏头痛疗法.
主要成果:
- 发放了超过14万个DDD,主要是给45岁以上的女性 (88%).
- 大多数用户 (79%) 之前曾使用过坦;69%在开始之前过度使用药物.
- 开始后急性药物过量使用的显著减少,但45%的人提前停止治疗.
结论:
- 里梅在丹麦迅速普及,特别是在中年女性中,这些女性有史以来使用过多的三类药物和过度使用药物.
- 虽然rimegepant的使用与急性药物过度使用的减少相关,但高的早期停止率突出显示了持续治疗的潜在障碍.
- 需要制定战略,以改善临床实践中长期遵守和获得rimegepant的机会.
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