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Updated: May 11, 2025

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
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工程FcRn结合动力学大大延长了抗体血清半衰期,并提高了治疗潜力

Sanghwan Ko1, Migyeong Jo2,3, Munsu Kyung1,4

  • 1Department of Biomedical Sciences, Graduate School, Korea University, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Journal of biological engineering
|April 18, 2025
PubMed
概括

设计了一种Fc变体 (YML) 来优化新生儿Fc受体 (FcRn) 的结合,通过超越内源IgG来显著延长抗体半衰期. 这一突破提高了治疗抗体的持续性和有效性.

关键词:
补充依赖的细胞毒性内源性IgG的竞争在FcRnnn中.血清半衰期 血清半衰期治疗性抗体治疗性抗体取决于pH的FcRn结合动力学

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