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牙成熟度对再生性内牙科治愈结果的影响

S Takahara¹, N Ohkura¹, N Yoshiba²

¹Division of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Journal of dental research

|April 19, 2025

概括

使用血凝块 (BC-REP) 和残留肉的再生内牙科,根据牙成熟度显示出不同的愈合. 成熟的牙倾向于牙周带状的愈合,而不成熟的牙由于转变的介质干细胞迁移而表现出类似肉质的愈合.

科学领域:

牙周内科医院牙周内科医院牙周内科医院
再生医学是一种再生医学.
干细胞生物学干细胞生物学

背景情况:

使用血栓 (BC-REP) 的再生内牙术程序 (REP) 通常会在不成熟的牙中诱导牙周带状愈合.
剩余的纸存在可以将愈合转向类似纸的模式.
牙发育阶段对BC-REP愈合表型的影响,特别是关于介质干细胞/干细胞 (MSCs) 的影响,仍然不清楚.

研究的目的:

为了研究牙成熟度对BC-REP后的愈合表型的影响,在残留肉的存在下.
在再生性内牙科手术过程中,分析MSC与牙发育阶段的迁移和行为.

主要方法:

建立了BC-REP大鼠鼠模型,在不同的发育阶段 (未成熟,接近成熟,成熟) 建立了残留肉质.
组织学分析检查了早期 (7天) 和晚期 (28天) 愈合阶段的愈合模式和MSC标记 (α-SMA,CD73,CD90,CD146).
免疫组织化学检测发现了增殖标志物 (Ki67,PCNA) 和巨细胞的存在.

主要成果:

与不成熟的牙相比,在成熟的牙中,类似牙周带的愈合更频繁.
未成熟的牙在愈合早期显示出与根管口附近的α-SMA共同表达的增殖标志物.
成熟的牙在顶部表现出增加的CD73,CD90和CD146阳性细胞,CD90/CD146阳性细胞在7天后表达了增殖标记.

结论:

牙成熟度显著影响BC-REP在残留肉存在后的愈合表型.
根据牙发育阶段,MSC的迁移模式不同,导致不同的再生结果.
了解这些依赖成熟度的变异对于优化再生性内牙治疗至关重要.

关键词:

牙纸是一种牙纸.巨细胞是什么?巨细胞是什么?介质细胞干细胞介质细胞干细胞牙周关节带牙周关节带纸的再生和再生伤口愈合伤口愈合

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