基于MRI的多中心,多供应商同时验证质子密度脂肪分数和R2*映射使用组合质子密度脂肪分数-R2*幻影映射
Jitka Starekova1, David Rutkowski2, Won C Bae3
1Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Journal of magnetic resonance imaging : JMRI
|April 19, 2025
概括
这项研究发现,对于质子密度脂肪分数 (PDFF) 和R2*的量化,在多个中心,供应商和场强度中都具有很好的可重复性. 随着PDFF和R2*值的提高,可复制性略有下降,特别是在高R2*条件下的PDFF.
科学领域:
- 磁共振成像 (MRI) 是一种磁共振成像技术.
- 定量成像技术 定量成像技术
- 生物医学工程 生物医学工程
背景情况:
- 脂肪和铁沉积可以影响MRI测量,如R2*和质子密度脂肪分数 (PDFF).
- 这些因素对PDFF和R2*量化可重现性的综合影响尚不清楚.
研究的目的:
- 评估PDFF和R2*量化的多中心,多供应商可重复性.
- 为了评估这些指标,使用专门设计用于控制脂肪和铁度的幻影.
主要方法:
- 一个前性的多中心研究,使用商业PDFF-R2*幻影.
- 幻影成像在四个中心进行,不同的供应商在1.5-T和3-T使用3D多回声破坏梯度回声序列.
- 两个协议被优化为中等和高R2*值,统计分析包括ICC,RDC和RC.
主要成果:
- 对PDFF (ICC=0.97) 和R2* (ICC=0.99) 在各中心,供应商,现场强度和协议之间观察到出色的协议.
- 对于PDFF的可复制性很好 (ICC=0.96-0.99) 和R2*的可复制性很强 (ICC=0.988-0.99),尽管随着PDFF和R2*值的增加,可变性增加.
- 稳定性测试显示,PDFF和R2* (ICC=1.0) 的复制性几乎是完美的.
结论:
- 在各种MRI设置中,PDFF和R2*量化的高可重现性是可以实现的.
- 采集协议和幻影特征显著影响这些定量MRI测量的精度.
- 这些发现支持PDFF和R2*在多中心研究和临床应用中的可靠使用.
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