癌症儿童的代谢与疲劳和身体功能的关联:试点研究
Janice S Withycombe1,2, Jinbing Bai2,3, Canhua Xiao2
1School of Nursing, Clemson University, Clemson, SC, USA.
Biological research for nursing
|April 19, 2025
概括
儿童癌症患者经历疲劳,这与身体功能和特定代谢物有关. 改善身体功能可能有助于管理这些孩子的疲劳.
科学领域:
- 儿科瘤学 儿科瘤学
- 代谢学 代谢学 代谢学
- 运动生理学 运动生理学
背景情况:
- 疲劳是接受癌症治疗的儿童常见的症状.
- 以前的研究表明,疲劳和体力活动之间存在反向关系.
- 儿童癌症患者的疲劳,身体功能和潜在的生物机制之间的联系需要进一步调查.
研究的目的:
- 探索在接受癌症治疗的儿童中疲劳,身体功能和相关代谢物的关联.
- 在这个人群中,确定与疲劳和身体功能相关的特定代谢物.
- 了解儿童癌症患者疲劳的生物学基础.
主要方法:
- 从儿童 (7-18岁) 采集了血清样本和自我报告的疲劳和身体功能 (流动性),使用PROMIS调查在两个时间点进行调查.
- 使用高分辨率液态色谱-质谱分析29种向代谢物.
- 使用线性混合效应模型来评估代谢物相关性,并对共变量进行调整.
主要成果:
- 在身体功能和疲劳之间观察到一个显著的反向关系 (T1:r = -0.64;T2:r = -0.63).
- 印度尔-3-乳酸在低和高疲劳水平之间进行了区分.
- 五种代谢物 (4-基子酸,m-酸,myoinositol,tryptophan和tyrosine) 与身体功能有显著的关联.
结论:
- 代谢物,特别是氨基酸,与儿童癌症患者的疲劳和身体功能有显著的关联.
- 所有已识别的显著代谢物都显示出与肠道微生物组的关联.
- 身体功能和疲劳之间的反向相关性表明身体功能是疲劳管理干预措施的潜在目标.
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