在Omicron疫情期间与SARS-CoV-2住院患者的恩西特雷尔维尔:单中心观察性研究
Masaya Yamato1, Masahiro Kinoshita2, Yuki Yoshida3
1Department of General Internal Medicine and Infectious Diseases, Rinku General Medical Center, Izumisano, Japan.
Infectious diseases and therapy
|April 19, 2025
概括
与remdesivir相比,恩西特利维尔在住院COVID-19患者的28日死亡率较低. 这种口服蛋白酶抑制剂提供了潜在的治疗选择,即使是严重的病例.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 恩西特里尔维尔是一种口服的3C类蛋白酶抑制剂,用于SARS-CoV-2,在日本可用.
- 这项研究在住院COVID-19患者中比较了恩西特利维尔与雷梅西维尔.
研究的目的:
- 为了评估患者的特征和恩西特里尔维尔与雷梅西维尔的治疗结果.
- 为了比较两种抗病毒治疗之间的死亡率,出院时间和病毒清除.
主要方法:
- 住院COVID-19患者的单中心图表审查 (2022年11月 - 2024年8月).
- 纳入标准:标签上的恩西特里尔维尔或雷德西维尔治疗.
- 评估结果:28日死亡率,出院时间,病毒清除,使用IPTW进行调整.
主要成果:
- 156名患者接受了恩西特里尔维尔,337人接受了雷梅西维尔;平均年龄~76岁.
- 较低的未调整的28日死亡率为恩西特雷尔维尔 (1.9%) 与雷梅西维尔 (5.9%).
- 恩西特雷尔维尔的排泄时间更短;群体之间的病毒清除时间相似.
结论:
- 恩西特利维尔显示28日死亡率较低,包括老年人和严重的COVID-19患者.
- 研究结果表明,恩西特里尔维尔在治疗住院COVID-19患者中的潜在作用.
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