相关实验视频
Updated: May 11, 2025

06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
23.2K
长期心脏代谢结果的初级双边上腺增生
Huixin Zhou1,2, Peng Zhang3, Yaqi Yin2
1School of Medicine, Nankai University, 94 Weijin Road, 300071, Tianjin, China.
Journal of endocrinological investigation
|April 19, 2025
概括
针对一次性双边巨性上腺增生症 (PBMAH) 的手术显著改善了血压和血糖控制. 上腺切除术为PBMAH患者提供心脏代谢益处,即使有轻微的自主皮质醇分泌.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 代谢健康 代谢健康
背景情况:
- 主要双边巨性上腺增生症 (PBMAH) 经常与心脏代谢性并发症有关.
- 手术与保守治疗对这些并发病的长期影响尚未完全理解.
研究的目的:
- 研究手术与保守治疗对PBMAH患者心脏代谢并发症的长期影响.
- 评估上腺切除术在治疗高血压,血糖代谢异常,血脂不良和PBMAH患者体重方面的有效性.
主要方法:
- 一项回顾性单中心研究包括132名PBMAH患者,分为手术 (n=68) 和对照 (n=64) 组.
- 测量结果包括血压,血糖,脂质和体重的变化.
- 对95名患有轻度自主皮质醇分泌的患者进行了亚组分析.
主要成果:
- 超过50%的PBMAH患者患有高血压,血糖异常,血脂不良或超重/肥胖.
- 与对照组相比,手术组的血压,血糖和体重明显改善.
- 上腺切除术与更好地控制血压,血糖和至少一个心脏代谢风险因素有关,包括在轻度自主皮质醇分泌的患者中.
结论:
- 大多数PBMAH患者至少存在一个心脏代谢风险因素.
- 上腺切除术与PBMAH患者的血压和血糖控制的改善有关,包括那些轻度自主皮质醇分泌的患者.
相关概念视频
Adrenal Gland Disorders
1.2K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.2K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
305
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
305
Hormonal Regulation
32.7K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.7K
Hormones of the Adrenal Glands
2.0K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.0K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
37
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
37

