母亲压力对非综合征裂的影响:一个回顾性病例控制研究
Ola B Al-Batayneh1,2, Tamara Halasa3, Serene Badran4,5
1Department of Preventive Dentistry, Faculty of Dentistry, Jordan University of Science and Technology, PO Box 3030, Irbid, 22110, Jordan. olabt@just.edu.jo.
概括
怀孕第一季度的孕产妇压力,加剧了COVID-19大流行,显著增加了婴儿非综合征性口腔裂 (NSOFCs) 的风险. 这强调了产前心理健康对胎儿发育的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19大流行,孕妇面临前所未有的心理压力.
- 孕产妇的心理压力 (MS) 是影响胎儿发育的潜在环境因素.
- 非综合征性口腔裂 (NSOFCs) 是一种常见的先天性异常,具有多因素的病因.
研究的目的:
- 调查COVID-19相关的孕产妇心理压力在头三个月和NSOFCs的发生之间的联系.
- 确定在大流行期间出生的婴儿中导致NSOFCs的危险因素.
主要方法:
- 一项追溯病例控制横截面研究,涉及192名婴儿 (64例NSOFC,128例对照).
- 通过电话问卷收集有关人口统计,风险因素和压力水平 (使用LEQ和FCV-19S) 的母亲数据.
- 统计分析包括描述性统计,相关性和后勤回归 (P ≤0.05).
主要成果:
- 由于COVID-19大流行,孕产妇的压力被确定为NSOFC的显著风险因素 (P=0.039).
- 其他确定的风险因素包括婴儿妊娠年龄低 (P=0.009),缺乏叶酸摄入量 (P=0.037),以及父母血缘关系 (P=0.019).
- 改变居住地和整体压力是两组母亲的重要因素 (P≤0.019).
结论:
- 怀孕早期母亲的心理压力是非综合征性口腔裂的潜在危险因素.
- 建议进行进一步的研究,以探索产前和产周压力对先天性异常的影响.
- 在怀孕期间解决母亲的心理健康问题对于改善婴儿的结果至关重要.
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