由脉动刺激引起的大脑连接的频率特异性变化
Emma Acerbo1, Aude Jegou1, Stanislas Lagarde1,2
1Aix Marseille Université, INSERM, Institut de Neurosciences des Systèmes, Marseille, France.
Epilepsia
|April 19, 2025
概括
高频深度大脑刺激 (DBS) 可以降低患者的大脑功能连接 (FC). 中间频率可能会增加FC,因此在管理中需要谨慎对立体刺激.
科学领域:
- 神经科学是一个神经科学.
- 发病学 (Epileptology) 是一个专业的学科.
- 神经外科 神经外科
背景情况:
- 深度脑刺激 (DBS) 是一种新兴的治疗药物耐药性的疗法.
- 通过减少过度的大脑功能连接 (FC),DBS可能会使患者受益.
- 在手术前的评估中,在质体 (中脉,PuM) 中使用立体电脑学 (SEEG) 电极.
研究的目的:
- 研究不同刺激频率对大脑FC的影响.
- 确定特定频率是否在药物耐药患者中更有效调节FC.
主要方法:
- 在14名患者中,SEEG被用于研究1-200Hz的PuM刺激效应.
- 使用非线性相关系数 (h2) 和节点强度计算来评估功能连接 (FC).
主要成果:
- 10Hz和>90Hz的刺激降低了FC;20-80Hz增加了FC.
- FC调制超出了发性区域,影响了所有大脑叶.
- 周围,岛屿和皮层下区域在高频刺激时显示出显著的变化.
结论:
- 高频刺激显示出在中降低间接FC的潜力.
- 中间频率可能会加剧FC,需要谨慎.
- PuM刺激影响FC模式,支持用于管理的高频thalamic刺激.
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