快速揭露安全个人护理产品的毒性
Gertrud E Morlock1, Luisa Zoller2
1Institute of Nutritional Science, Chair of Food Science, and Interdisciplinary Research Center, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany; Center for Sustainable Food Systems, Justus Liebig University Giessen, Senckenbergstr. 3, 35390 Giessen, Germany.
个人护理产品含有危险化合物,包括遗传毒性和雌激素物质,对消费者和环境构成风险. 新的安全查显示,这些产品的安全性低于声称的安全性,需要行业和监管机构采取行动.
科学领域:
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
- 消费者产品安全 产品安全
背景情况:
- 个人护理产品 (PCP) 有长时间的皮肤接触,但危害数据很少.
- 现有的安全评估可能无法充分捕捉与PCP相关的潜在风险.
研究的目的:
- 开发和应用一种成像安全选方法,用于检测PCP中的危险化合物.
- 在20个产品细分市场中评估140个PCP的安全性.
主要方法:
- 开发了一种基于证据的染色体与危险相关的分析技术.
- 在PCP中检测到基因毒性,细胞毒性和雌激素化合物.
- 将检测到的化合物分配到结构组,并评估剂量反应关系.
主要成果:
- 在各种PCP中发现了危险化合物,包括遗传毒性和雌激素物质.
- 乳头奶油和口红等产品含有高度有毒的化合物.
- 模拟代谢并没有对已识别的危险化合物进行排毒.
结论:
- PCPS并不像通常所说的那样安全,含有可以进入血液的有毒化合物.
- 开发的选方法有效地识别产品的毒性,并指导创建更安全的替代品.
- 需要加强监管监督和行业责任,以确保消费者健康和环境安全.
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