在一个大型的,有前景的注册表中,在患有前列腺癌和没有前列腺癌的男性中,可修改的心血管风险因素
James Janopaul-Naylor1, Adithya K Yadalam2, Jeffrey Shi Kai Chan3
1Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
患有前列腺癌的男性胆固醇水平较高,但可能未充分利用降胆固醇药物. 解决心血管风险因素对于改善这一群体的预期寿命至关重要.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 心血管疾病是前列腺癌男性非癌症死亡的主要原因.
- 确定可修改的心血管风险因素对于这个患者群体至关重要.
研究的目的:
- 为了比较患有前列腺癌和没有前列腺癌的男性之间可修改的心血管风险因素.
- 为了评估吸烟状况,脂质概况和高血压的差异.
主要方法:
- 利用了来自186830名男性的英国生物库数据 (2006-2010年).
- 在患有 (N=2,720) 和没有 (N=13,600) 前列腺癌的男性之间进行了年龄相匹配的比较 (1:5).
- 对患有和没有失脂血症的男性进行分层分析.
主要成果:
- 患有前列腺癌的男性总和LDL胆固醇水平较高 (P=.006).
- 他们不太可能吸烟或患糖尿病,但在使用降胆固醇药物方面没有差异.
- 在失脂症小组中,患有前列腺癌的男性总胆固醇较高 (P=.004).
结论:
- 患有前列腺癌的男性可能会增加总胆固醇和LDL胆固醇,并可能未充分利用降胆固醇药物.
- 针对瘤和心血管健康的综合护理至关重要.
- 个性化风险因素修改是优化预期寿命的关键.
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