在老年人中,有明显的肠道微生物群特征,有sarcopenic肥胖症和没有肥胖症的sarcopenia
Ling Wang1, Xiangfeng He2, Zhen Zhang2
1Department of Rehabilitation, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China; School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Clinical nutrition (Edinburgh, Scotland)
|April 19, 2025
概括
在老年人中,肠道微生物群的组成有显著差异,这些老年人患有皮症 (Sar) 和皮性肥胖症 (SO). 这些发现表明肠道细菌可能是这些与年龄有关的疾病的治疗点.
科学领域:
- 老年学是指老年学的学科.
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 肠道失生症与sarcopenia和sarcopenic肥胖症 (SO) 有关.
- 目前,有限的证据支持这种关联.
- 这项研究研究了老年人的肠道微生物群,这些老年人患有肉类和SO.
研究的目的:
- 为了描述肠道微生物群的多样性和组成,在老年人与sarcopenia (Sar) 和SO.
- 为了确定与Sar和SO相关的特定微生物种群.
- 探索肠道微生物群作为治疗点的潜力.
主要方法:
- 来自上海的60名老年人 (≥65岁) 的肠道微生物群的16S rRNA测序.
- 参与者分为SO (n=20),Sar (n=18) 和对照组 (n=22).
- 分析包括α/β多样性,LEfSe和随机森林模型.
主要成果:
- 在Sar,SO和对照组之间发现了肠道微生物群多样性和组成的显著差异.
- SO组显示α多样性减少;β多样性有显著差异.
- 在Sar和SO组中,特定的细菌种群被丰富或耗尽,预测模型的诊断准确度很高 (Sar的AUC为0.860,SO为0.826).
结论:
- 肠道微生物群的特征在患有肉症和肉性肥胖症的个体中是不同的.
- 这些发现为肠道微生物组在SO中的作用提供了新的见解.
- 肠道微生物群代表了治疗肥胖症的潜在治疗途径.
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