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Updated: May 10, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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SWI/SNF PBAF复合物促进了镇压性染色质的REST占用

Elena Grossi1, Christie B Nguyen2, Saul Carcamo3

  • 1Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Molecular cell
|April 19, 2025
PubMed
概括

聚菌相关BAF (PBAF) 复合体,特别是其ARID2成分,在调节黑色素瘤中的基因表达方面发挥着至关重要的作用. 失去ARID2会破坏神经元基因的沉默,影响黑色素瘤的进展和大脑转移.

关键词:
在 ARID2 的 ARID2 里面.在PBAF中,PBAF是PBAF.多重复合的多重复合.休息时间 休息时间在 SWI/SNF 中.染色体重塑剂的使用方法黑色素瘤是一种黑色素瘤.转录因子是一种转录因子.

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