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Updated: May 20, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

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由TARDBP突变引起的肌缩侧硬化症:从遗传学到TDP-43蛋白质病变

Rubika Balendra1, Jemeen Sreedharan2, Martina Hallegger3

  • 1Human Stem Cells and Neurodegeneration Laboratory, The Francis Crick Institute, London, UK; UK Dementia Research Institute at UCL, London, UK.

The Lancet. Neurology
|April 19, 2025
PubMed
概括

TARDBP基因 (TDP-43) 中的突变与肌缩性侧面硬化症 (ALS) 有关. 在大多数ALS病例中,TDP-43蛋白错位和聚合是关键的病理特征,导致神经退行.

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