在早产的青少年和成年人中,右心室尺寸和功能减少
Zachary W Blair1, Alvin Chandra2, Gregory P Barton3
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas.
概括
过早分娩与右侧心室的缩小以及青少年和成人功能减弱有关,独立于肺高血压. 这些发现表明,过早出生的人对心脏有长期影响.
科学领域:
- 心脏病学 心脏病学
- 新生儿科学 新生儿科学
- 儿科健康 儿科健康
背景情况:
- 过早出生的成年人往往表现出较小的心室,并可能发展出右心室 (RV) 功能障碍.
- 在早产儿中导致成人期RV功能障碍的危险因素尚未完全理解.
研究的目的:
- 调查早产青少年和成人的右侧心脏结构和功能.
- 为了确定早产和心脏异常之间的关联.
主要方法:
- 招募了早产 (怀孕≤32周或<1500克) 和12-40岁的健康的出生参与者.
- 进行人体测量测量,心肺检查和心声回声.
- 利用多变量线性回归来分析早产对右心房和RV结构/功能的影响,并对共变量进行调整.
主要成果:
- 预产期参与者 (n=107) 与预产期对照者 (n=48) 相比,右心房体积和RV面积较小.
- 在早产个体中观察到减少三环状平面缩外流,RV s'和RV e'.
- 在妊娠年龄和这些功能缺陷之间发现了剂量反应关系,即使没有明显的肺高血压.
结论:
- 过早出生的青少年和成年人有较小的右侧心室和受损的RV功能.
- 在早产的个体中,减少RV功能与妊娠年龄有关,并且独立于肺高血压发生.
- 过早分娩似乎对发育中的右心室造成了独立的侮辱,并可能导致终身心血管后果.
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