流中的恶性细胞数量:死亡率的潜在指标
Celal Satici1, Sinem Nedime Sokucu1, Ibrahim Aras1
1University of Health Sciences, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Pulmonology, Istanbul, Turkey.
The American journal of the medical sciences
|April 19, 2025
概括
胸腔液中较低的恶性细胞数量 (<1700个细胞/2mm2) 与恶性胸腔溢出 (MPE) 患者的死亡率增加有关. 男性性别和活跃吸烟也预测生存率较低.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 细胞病理学 细胞病理学
背景情况:
- 腹液中恶性细胞计数对生存的预后价值尚未得到充分确立.
- 恶性流 (MPE) 诊断需要准确的预后指标.
- 这项研究调查了膜液恶性细胞数量与MPE患者死亡率之间的关联.
研究的目的:
- 为了评估在多流中恶性细胞数量和患者死亡率之间的关系.
- 确定诊断为MPE的患者生存的独立预测因素.
主要方法:
- 在第三级转诊医院对未经治疗的MPE患者进行了回顾性队列研究.
- 用单变量和多变量考克斯回归分析来确定死亡率预测因素.
- 患者按恶性细胞数分层 (<1700个细胞/2mm2与≥1700个细胞/2mm2).
主要成果:
- 该研究包括63名MPE患者 (61.9%男性,平均年龄65.7岁),NSCLC是最常见的诊断 (76.2%).
- 多变量分析确定了男性性别 (HR:4.14),活跃吸烟 (HR:2.99) 和恶性细胞数量 (HR:0.23) 作为死亡率的独立预测因素.
- 恶性细胞数量<1700个细胞/2mm2与死亡风险增加有关.
结论:
- 恶性细胞数量<1700个细胞/2mm2,男性性别和活跃吸烟是MPE增加死亡率的独立预后因素.
- 这些发现突显了细胞学恶性细胞计数在MPE预后中的潜在临床相关性.
- 需要进一步的前性研究来验证这些结果并探索这些细胞的功能意义.
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