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在水生环境中追踪抗生素和抗生素耐药性大肠杆菌与农业相关

Laurens Tuts¹, Marc Heyndrickx², Ilse Becue³

¹Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), Technology and Food Science Unit, Brusselsesteenweg 370, Merelbeke-Melle, 9090, Belgium; Ghent University, Faculty of Bioscience Engineering, Center for Microbial Ecology and Technology (CMET), Frieda Saeysstraat 1, 9052, Ghent, Belgium.

Environmental pollution (Barking, Essex : 1987)

|April 19, 2025

概括

肥料的应用将抗生素残留物和耐药细菌引入水中. 这项研究发现,表面水中存在广泛的污染,受精后大肠杆菌的抗生素耐药性增加,突出了水生生态系统的风险.

科学领域:

环境科学环境科学
微生物学微生物学
公共卫生公共卫生

背景情况:

农业肥料应用是已知的抗生素残留物和抗生素耐药细菌 (ARB) 的来源.
这些污染物可以进入水生生态系统,对环境和人类健康构成风险.
环境中抗生素耐药性的传播是一个日益严重的全球性问题.

研究的目的:

在肥后的地表水和地下水中调查抗生素残留物和ARB的存在和水平.
评估农业实践对指标细菌抗生素耐药性的流行和模式的影响.
评估抗生素污染对水生生态系统构成的风险,并为政策提供信息.

主要方法:

50个地表水位 (施肥前和施肥后) 和50个地下水井的采样.
对一系列抗生素残留物的分析,使用对低度 (0.01-10μg/L) 敏感的方法.
检测和抗生素耐药性分析指标细菌,包括大肠杆菌和扩展谱β-乳糖酶 (ESBL),产生大肠杆菌.

主要成果:

在淡水生态系统中广泛检测到各种抗生素残留物;只有16%的样本没有残留物.
硫胺和林氏素经常被检测到,其度有时超过了对抗菌素耐药性选择的预测无效水平.
大肠杆菌在受精后 (20%至48%) 显著增加了对硫甲醇的耐药性,这表明便对抗生素耐药性增加的贡献.
虽然在地下水中不太普遍,但抗生素耐药性很普遍,ESBL产生的大肠杆菌表现出高耐药性,包括对关键的最后避险抗生素.

结论:

农业肥料应用是抗生素残留物和ARB进入水生环境的重要途径.
环境中的抗生素污染有助于抗生素耐药性的选择和传播,包括地下水.
迫切需要监测,立法和缓解策略,以制抗生素污染和打击水生生态系统中的耐药性.

关键词:

农业的下水是农业的下水.抗生素抗生素是一种抗生素.美国大肠杆菌 (E. coli).这就是ESBL.淡水淡水的水是什么电阻电阻电阻电阻电阻电阻

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