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治疗后不良事件在肝细胞癌向免疫治疗中的排名:基于风险概率评估的网络元分析

Gaoyuan Yang¹, Yupeng Ren¹, Yuxuan Li¹

¹Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.

Critical reviews in oncology/hematology

|April 19, 2025

概括

对于肝细胞癌 (HCC) 的卡博赞提尼布和卡姆雷利祖马布疗法显示出更高的不良事件. 对HCC的杜尔瓦卢马布和伦瓦替尼治疗与较少的常见副作用有关,有助于治疗决策.

科学领域:

肝胆道癌症肝胆道癌症
医学瘤学医学瘤学
药物监督药物监督药物监督

背景情况:

针对性和免疫疗法正在迅速发展,用于肝细胞癌 (HCC).
对于这些HCC治疗方法,对不良事件概况的系统比较有限.
这次审查优先考虑基于不良事件数据的HCC治疗安全性.

研究的目的:

系统地比较针对HCC的向和免疫疗法的不良事件概况.
通过优先考虑基于安全性的HCC治疗方案来指导临床决策.
综合来自随机对照试验 (RCT) 关于HCC治疗安全性的数据.

主要方法:

对13项针对HCC向性和免疫治疗的RCT (2008-2023) 的系统审查和元分析.
数据来源于PubMed,Embase,Web of Science和Cochrane图书馆,遵循PRISMA的指导方针. 这些数据来自PubMed,Embase,Web of Science和Cochrane图书馆,遵循PRISMA的指导方针.
网络元分析用于评估不良事件作为主要终点和排名治疗风险.

主要成果:

分析了13个涉及10,760名患者的RCT和13个HCC治疗方案.
不良事件被整合,并构建网络模型来评估风险概率.
针对性免疫治疗方案的优先排名是基于各种不良事件而建立的.

结论:

卡博赞提尼布,卡姆雷利祖马布及其对HCC的联合治疗与更高的常见不良反应发生率有关.
杜尔瓦卢马布,伦瓦替尼和它们对HCC的联合治疗与常见不良反应的可能性较低有关.
研究结果有助于选择更安全的HCC治疗方案.

关键词:

不良事件是不良事件.肝细胞癌是肝细胞癌.免疫治疗是一种免疫疗法.有针对性的治疗方法.

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