肠道微生物组,表观遗传学和物质使用障碍之间的相互作用:从分子到临床的角度
Keivan Sahebi1, Mona Arianejad2, Soha Azadi3
1School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
European journal of pharmacology
|April 19, 2025
概括
肠道微生物群通过微生物群-肠道-大脑轴 (MGBA) 影响物质使用障碍 (SUDs),影响表观遗传学. 针对微生物组的治疗对SUD有希望,但长期表观遗传效应需要进一步研究.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 遗传学 遗传学 是一个
背景情况:
- 药物使用障碍 (SUD) 涉及影响认知,行为和生理功能的复杂病理.
- 微生物组-肠-大脑轴 (MGBA) 在SUD中发挥着越来越公认的作用,通过代谢物如短链脂肪酸 (SCFA),细胞因子和神经递质来影响系统.
- 这些介质会影响表观基因组和转录基因组,在受SUDs影响的大脑区域观察到表观基因变化.
研究的目的:
- 综合讨论肠道微生物群对SUD的影响,重点关注表观遗传变化.
- 检查肠道微生物组和SUD之间的双向关系,确定潜在的干预目标.
- 审查肠道微生物组导向治疗SUD的进展,包括其局限性和未来研究方向.
主要方法:
- 对肠道微生物组,MGBA和SUDs的现有文献的审查.
- 对表观遗传机制的分析,将肠道微生物组失调与SUD联系起来.
- 对SUDs的现有和新兴微生物向干预措施的评估.
主要成果:
- 肠道微生物组通过MGBA显著影响SUDs,影响表观遗传修饰.
- 肠道微生物组导向的干预措施 (益生菌,益生菌,抗生素,FMT) 在SUD患者中显示出有前途的结果.
- 这些干预措施的长期表观遗传效应和精确的分子机制在很大程度上仍未被探索.
结论:
- 肠道微生物组是SUD病变发生的关键因素,并呈现出潜在的治疗点.
- 需要进一步的研究来阐明长期的表观遗传效应,并优化基于SUDs的微生物组干预措施.
- 解决混因素和研究局限性对于SUD中微生物组疗法的临床转化至关重要.
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