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在高近视眼中不同年龄组的进展率:一项为期10年的随访队列研究

Jaekyoung Lee¹, Young In Shin², Min Gu Huh³

¹Department of Ophthalmology (J.L., Y.I.S., M.G.H., Y.J., Y.K.K., J.W.J., K.H.P.), Seoul National University College of Medicine, Seoul, Korea; Department of Ophthalmology (J.L.), Keimyung University Dongsan Medical Center, Daegu, Korea.

American journal of ophthalmology

|April 19, 2025

概括

高度近视的正常张力玻璃眼 (NTG) 患者在年轻人中表现出更快的进展,观察到双模模式. 基线眼内压力 (IOP) 和视野指数 (VFI) 影响功能性进展率.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
近视研究近视研究

背景情况:

高近视是青光眼的危险因素.
正常张力玻璃眼 (NTG) 在进展监测方面提出了独特的挑战.
了解与年龄相关的进展模式对于管理高度近视型玻璃眼患者至关重要.

研究的目的:

确定高近视性NTG患者不同年龄组的结构和功能进展率.
识别影响功能参数变化速度的风险因素.
为了分析呈现时的年龄和青光眼的进展之间的相关性.

主要方法:

在320名高度近视的NTG患者的回顾性临床队列研究中,至少进行了8年的随访.
患者分为"年轻" (40岁以下) 和"老" (40岁以上) 的年龄组.
视野指数 (VFI),平均偏差 (MD) 和视网膜神经纤维层 (RNFL) 厚度的评估进展率;使用回归和Cox建模.

主要成果:

青光眼的进展率 (VFI,MD,RNFL) 与呈现时的年龄正相关.
较年轻的患者与老年患者相比,MD变化的平均速度更快 (-0.36dB/年), (-0.22dB/年).
观察到双向性进展模式,在19-29岁和40-49岁年龄组的比率更快,在30-39岁和50岁以上的年龄组的比率更慢. 基线IOP和VFI显著预测了MD变化率.

结论:

在高度近视的NTG患者中,青光眼的进展遵循一种由呈现时的年龄影响的双模模式,年轻患者的进展更快.
基线眼内压和视野指数是功能进展的重要预测指标.
这些发现有助于为高度近视的NTG患者量身定制治疗策略.

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