在干燥的黑中形成基于多的纳米颗粒,比自由多醇增强细胞吸收
Xiangyu Meng1, Sihao Luo2, Zhaoshuo Yu3
1UCD School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland.
International journal of biological macromolecules
|April 19, 2025
概括
干燥的棘衍生纳米粒子 (DHNPs) 增强了多的吸收. 这些富含多的纳米颗粒通过内细胞分裂显著增加了肠道透性,改善了生物可用性.
科学领域:
- * 纳米技术的使用
- * 植物化学 植物化学
- * 药理学 药理学 药理学
背景情况:
- *植物衍生纳米颗粒 (PDNP) 显示出生物活性化合物输送的前景.
- * 通过PDNP促进生物可用性增强的机制尚不清楚.
- *棘是一种丰富的生物活性多的来源.
研究的目的:
- * 用于描述干燥的棘衍生纳米粒子 (DHNPs).
- * 调查DHNP内部的分子相互作用.
- *评估DHNP对多醇吸收和生物可用性的影响.
主要方法:
- * DHNP 的物理化学特征 (大小,组成).
- *分析聚醇含量和相互作用 (共价,非共价).
- *使用Caco-2细胞单层的体外肠道吸收研究.
主要成果:
- *DHNP的平均值为275.7nm,含有约25%的多,主要通过共价和非共价相互作用结合.
- * 肥化处理增强了多的释放.
- * 代谢学发现了252种多化合物,其中195种治疗后水平增加.
- *在Caco-2细胞中,DHNP显著增加了多透率 (27.90%) 与自由多 (12.38%) 相比.
结论:
- *DHNP是有效的载体,可以增强多的吸收.
- *内细胞分裂是DHNP介导的多醇吸收的一个可能机制.
- *研究结果为改善生物活性化合物输送和生物可用性的PDNP应用提供了洞察力.
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