使用近红外光谱和化学测量对尿路结石的分类:用于手术内应用的一个有希望的方法
Ekaterina Boichenko1, Mikhail Paronnikov2, Anna Reznichenko1
1Institute of Chemistry, Saint Petersburg State University, Universitetskaya nab., 7-9-11, 199304, Saint Petersburg, Russia.
Analytica chimica acta
|April 19, 2025
概括
近红外光谱学 (NIRS) 在手术期间提供尿路结石的实时分析. 这种方法准确地分类石头类型,如氧酸盐,酸盐和酸盐,有助于立即处理决策.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 分析化学 分析化学
- 医学光谱学 医学光谱学
背景情况:
- 尿路结石化学成分的手术内分析对于定制手术策略和患者管理至关重要.
- 目前的术后分析方法推迟了关键的治疗决策.
- 近红外光谱 (NIRS) 提供了一种快速,非破坏性的分析技术,适用于手术内使用.
研究的目的:
- 评估NIRS在模拟和实际手术条件下对主要尿路结石类型 (氧沙酸盐,尿酸盐,酸盐) 的实时分类中的有效性.
- 评估NIRS与外科手术流程的兼容性,并将其结果与已建立的X射线相位分析进行比较.
主要方法:
- 使用分散反射模式的NIRS从尿路结石样本中获取光谱.
- 在环境和盐水条件下收集了光谱,以模仿手术期间的环境.
- 一个多项分类器 (纠错输出代码) 被训练并使用化学算法进行验证.
主要成果:
- 该NIRS方法证明了可接受的精度和回忆力,用于分类酸盐 (94%),酸盐 (87%) 和酸盐 (71%),即使在盐溶液中.
- 通过皮肤利切除术的实时手术内应用显示与外科手术方案的兼容性.
- 获得的NIR光谱显示与参考X射线相位分析结果有很好的一致性.
结论:
- NIRS是一个可行的工具,用于实时,手术期间分类尿路结石.
- 这项技术可以立即提供洞察力,以指导手术决策和针对患者的具体建议.
- 将NIRS整合到外科实践中,有望改善尿病管理.
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