饮食乳化剂 聚酸盐80诱导的脂毒性促进肠道衰老
Linlin He1, Lan Zhang2, Fanyi Meng1
1Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, National Key Clinical Specialty, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin 300052, China.
Food research international (Ottawa, Ont.)
|April 19, 2025
概括
食品添加剂聚酸盐80 (P80) 通过破坏肠道屏障并增加氧化应激,加速肠道衰老. P80激活PPARα-FABP1通路,导致脂肪酸积累和肠道衰老.
科学领域:
- 胃肠病学 胃肠病学
- 细胞生物学 细胞生物学
- 毒理学 毒理学 毒理学
背景情况:
- 由氧化压力标志着肠道衰老,与IBD和结直肠癌等胃肠道疾病有关.
- 食品添加剂,特别是聚酸80 (P80) 对肠道衰老的影响尚不清楚.
- 以前的研究表明,食品添加剂可能会影响肠道健康.
研究的目的:
- 为了研究P80暴露对肠道衰老的影响.
- 为了阐明P80诱导的肠道衰老的潜在机制.
- 探索潜在的治疗目标,以减轻P80的不良影响.
主要方法:
- 利用了一个老化加速的鼠标易受影响的模型.
- 评估了肠道屏障完整性,氧化应激标志物和衰老指标.
- 研究过氧酶增殖器激活受体-α (PPARα) 和脂肪酸结合蛋白1 (FABP1) 轴的作用.
- 研究了PPARα抗剂 (GW6471) 的作用.
主要成果:
- 暴露于P80会损害肠道屏障并增加氧化应激.
- P80加速了肠道衰老和上皮细胞衰老.
- P80激活了PPARα-FABP1轴,增强了肠道脂肪酸的吸收,导致脂毒性.
- 用GW6471抑制PPARα减少了P80诱导的脂肪酸吸收和衰老.
结论:
- 食品添加剂P80可以加速肠道衰老.
- P80的机制涉及激活PPARα-FABP1轴,导致肠道脂肪酸吸收和脂毒性增加.
- 这些发现突出了食品添加剂对肠道健康的潜在风险,并建议PPARα作为治疗点.
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