西里 (Rosa roxburghii Tratt.) 的意思就是西里. 聚醇可以通过肠道微生物群-脂质介质-免疫轴改善结肠炎
Huanzhi Yang1, Yang Zhao1, Ruiqi Zhang1
1College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
果汁中的多可以通过恢复肠道微生物组平衡来对抗结肠炎. 这些化合物降低了炎症和氧化应激,突出了它们在治疗炎症性肠病方面的潜力.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 肠道微生物组失调是炎症性肠道疾病 (IBD) 的关键因素.
- 来自水果和蔬菜的植物化学物质对IBD管理具有前景,但它们对肠道微生物群的机制尚未完全理解.
研究的目的:
- 研究CiLi果汁聚醇 (CL_PP) 对硫酸 (DSS) 诱导的大肠炎的影响.
- 阐明肠道微生物群在调解CL_PP的抗结肠炎作用中的作用.
主要方法:
- 在用CL_PP.治疗的小鼠中使用DSS诱导的大肠炎模型.
- 对肠道微生物群的多样性,便短链脂肪酸和结肠组织标记物的分析.
- 脂质代谢物和基因表达的多组学分析.
- 便微生物群移植 (FMT) 和抗生素治疗实验.
主要成果:
- CL_PP缓解了结肠炎,保持了肠道屏障的完整性,减少了炎症和氧化应激.
- CL_PP丰富了有益的肠道细菌 (例如,Clostridia_UCG-014) 并减少了有害的细菌 (例如,Escherichia-Shigella).
- CL_PP调节的生物活性脂质代谢物和下调的氧化应激和免疫细胞标记物.
- 接受CL_PP治疗的小鼠的FMT赋予了抗结肠炎的效果,这些效果在抗生素治疗后消失了.
结论:
- 果汁中的聚醇通过调节肠道微生物群来有效改善结肠炎.
- 通过肠道微生物群,CL_PP具有抗炎和抗氧化作用.
- CL_PP显示出作为治疗大肠炎和炎症性肠病的治疗剂的潜力.
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