冬季增加风险:常见的呼吸道病毒和住院儿童的临床结果
Furkan Kalayci1, Aslinur Ozkaya Parlakay2, Metin Yigit3
1Department of Pediatrics, Ankara Bilkent City Hospital, Bilkent, Ankara, 06800, Turkey. drfurkankalayci@gmail.com.
BMC infectious diseases
|April 19, 2025
概括
这项研究分析了1465名住院患有急性呼吸道感染 (ARI) 的儿童. 人类口腔病毒 (hBoV) 和流感病毒 (IFV) 是常见的,hBoV与更高的重症监护需求和死亡率有关,特别是在患有慢性疾病的儿童中.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 急性呼吸道感染 (ARI) 是全球儿童住院,发病和死亡的主要原因.
- 导致ARI的常见病毒病原体包括流感病毒 (IFV),人类口腔病毒 (hBoV),人类甲肺病毒 (hMPV),人类鼻膜病毒 (hRV) 和人类呼吸道同胞病毒 (hRSV).
研究的目的:
- 评估住院的儿科患者的临床特征,实验室发现和治疗结果,这些患者患有由常见呼吸道病毒引起的ARI.
- 识别特定的病毒病原体及其与疾病严重程度和患者特征的关联.
主要方法:
- 在2019年8月至2024年3月期间,对1465名住院治疗ARI的儿科患者进行了回顾性分析.
- 多重实时PCR被用于识别从鼻抽样中的病毒病原体.
- 审查了临床数据,包括人口统计,并发症,重症监护室 (ICU) 入院和呼吸支持.
主要成果:
- 在30.1%的病例中检测到流感病毒 (IFV),在28.3%的病例中检测到人类口腔病毒 (hBoV),在18.4%的病例中检测到人类呼吸道同胞性病毒 (hRSV),在14.4%的病例中检测到人类鼻膜病毒 (hRV),在8.8%的病例中检测到人类肺膜病毒 (hMPV).
- hBoV和hRSV感染与急症监护和侵入性机械通风的需求增加有关,特别是在患有慢性健康状况的患者中.
- 总体死亡率为8.7%,hBoV显示出与死亡率的最高关联,特别是在患有慢性疾病的儿童中.
结论:
- 住院儿童的病毒性ARI通常是由IFV,hBoV,hRSV,hRV和hMPV引起的,冬季发病率较高.
- 在患有慢性健康状况的儿童中,由于风险增加,hBoV和IFV感染需要密切监测.
- 精心管理hBoV和hRSV感染至关重要,因为它们与严重的结果有关,并且需要加强重症监护支持.
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