Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Butyrate-producing <i>Faecalibacterium prausnitzii</i> suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway.

Gut·2024
Same author

Comment on: Alnustone inhibits the growth of hepatocellular carcinoma via reactive oxygen species-mediated PI3K/Akt/mTOR/p70S6K axis.

Phytotherapy research : PTR·2022
Same author

[Model establishment of liver fibrosis in oral arsenic solution exposed mice].

Zhonghua yi xue za zhi·2009
Same author

Effect of human cytomegalovirus infection on nerve growth factor expression in human glioma U251 cells.

Biomedical and environmental sciences : BES·2009
Same author

[Study on the mechanism of arsenic trioxide inhibiting NB4 cells proliferation].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2009
Same author

Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.

Die Pharmazie·2009
Same journal

The lncRNA-m6A axis in cancer: a bidirectional regulatory network in tumor progression and therapeutic resistance.

Journal of translational medicine·2026
Same journal

Repurposing cepharanthine as a radiosensitizer in esophageal squamous cell carcinoma through dual metabolic intervention and direct targeting of p70s6K.

Journal of translational medicine·2026
Same journal

Cellular crosstalk and signaling networks in the rheumatoid arthritis synovial microenvironment.

Journal of translational medicine·2026
Same journal

Pilot spatial transcriptomics of dental pulpitis suggests immune-fibroblast profiling linked to reversibility.

Journal of translational medicine·2026
Same journal

Beyond semen analysis: in men with normal semen parameters telomere attrition and oxidative imbalance distinguish those fertile from those with infertility.

Journal of translational medicine·2026
Same journal

Dual-block HER2 assessment reveals clinically relevant intratumoral heterogeneity in gynecologic cancers: a single-center landscape analysis.

Journal of translational medicine·2026
查看所有相关文章

相关实验视频

Updated: Jun 29, 2026

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.8K

空间转录学研究卡斯特曼病的研究.

Yanfang Chen1, Zhe Zhang2, Ling Li1

  • 1Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Journal of translational medicine
|April 19, 2025
PubMed
概括
此摘要是机器生成的。

空间转录学揭示了卡斯特曼病 (CD) 的发病,这表明B细胞是病变细胞,肌纤维细胞驱动病变的进展. 这为CD研究和药物开发提供了新的途径.

关键词:
卡斯特曼病是什么?卡斯特曼病是什么?异质性 异质性 异质性伤害细胞是一种伤害细胞.病变的发生和发病.空间转录组空间转录组

更多相关视频

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
09:45

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

2.9K
Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.3K

相关实验视频

Last Updated: Jun 29, 2026

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
09:19

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

Published on: July 6, 2022

4.8K
Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
09:45

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

2.9K
Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics
07:43

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

Published on: May 3, 2024

2.3K

科学领域:

  • 免疫学 免疫学 免疫学
  • 病理学 病理学 病理学
  • 基因组学就是基因组学.

背景情况:

  • 卡斯特曼病 (Castleman Disease,简称CD) 是一种罕见的淋巴增殖性疾病,原因不明,通常呈无痛淋巴腺病变.
  • 了解CD的发病过程对于开发有效的治疗方法至关重要.

研究的目的:

  • 使用空间转录学研究卡斯特曼病 (CD) 的病变发生.
  • 确定CD开发中的关键细胞参与者和相互作用.

主要方法:

  • 空间转录组学分析是在甲固定型氨酸嵌入式 (FFPE) 淋巴结样本上进行的.
  • 样本包括三个CD患者具有不同的组织类型和一个正常的淋巴结进行比较.

主要成果:

  • 确定了14个不同的细胞群,包括B细胞,血细胞,各种免疫细胞和介质细胞.
  • 有证据表明B细胞可能是CD中主要的损伤细胞.
  • 发现介质细胞,特别是肌纤维细胞,在疾病进展中具有重要作用,在不同CD亚型的细胞通信中显著异质.

结论:

  • 这项研究增强了对卡斯特曼病病原体的理解.
  • 这些发现为未来的CD研究和向治疗的开发提供了新的见解.