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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
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Structure-Activity Relationships and Drug Design01:28

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Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
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优化类醇-酸泡片的特性:通过设计的质量方法.

Nur Tasnim Adlina Mazdi1, Nur Aisyah Mior Mat Zin1, Muhammad Aiman Khairul Hisham1

  • 1Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.

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概括

通过设计优化了使用Quality-by-Design的青-青酸泡片. 确定了诸如结合剂度和颗粒化时间等关键因素,以改善药片硬度,分解和溶解率,以改善药物输送.

关键词:
泡的药片 泡的药片亚斯科布酸是什么 亚斯科布酸关键的质量属性 关键的质量属性帕拉西托摩尔是一种可怕的药物.通过设计的质量.

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科学领域:

  • 制药科学 制药科学
  • 制定 发展 制定 发展
  • 通过设计的质量 (QbD)

背景情况:

  • 泡片提供快速的药物释放和改善生物可用性.
  • 优化配方参数对于产品质量和性能的一致性至关重要.
  • 降醇 - 酸 (PCM-AA) 组合需要谨慎的配方,以确保稳定性和有效性.

研究的目的:

  • 通过设计质量 (QbD) 方法,优化对甲-甲酸 (PCM-AA) 泡片的特性.
  • 研究关键工艺参数对平板硬度,分解和溶解的影响.
  • 为PCM-AA泡片建立一个优化的配方.

主要方法:

  • 实施QbD原则,包括确定关键质量属性 (CQA) 和关键材料属性 (CMA).
  • 使用石川图和风险估计矩阵进行风险评估.
  • 响应表面方法 (RSM) 采用中央复合设计 (CCD) 来研究粘合剂度,颗粒化时间和泡剂比率的影响.
  • 针对物理性质和药物含量优化的药片的表征.

主要成果:

  • 鉴定了粘合剂度,颗粒化时间和泡剂比率作为影响平板电脑性能的关键因素.
  • 在PCM和AA两种情况下,实现了具有可接受硬度 (45±20N),分解 (<5分钟) 和溶解 (<10分钟) 的优化片.
  • 验证了配方模型,没有显著差异 (p>0.05),证实了一致的结果.

结论:

  • 在QbD方法成功优化PCM-AA泡片.
  • 颗粒化时间,粘合剂度和杂剂比率显著影响药片质量属性.
  • 这项研究提供了一个强大的框架,用于开发和优化泡类药片配方.