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Updated: Apr 28, 2026

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药物开发中的DILI预测:现在和未来

Jack Uetrecht1

  • 1Faculty of Pharmacy, University of Toronto, Toronto, ON, USA.

Expert opinion on drug metabolism & toxicology
|April 20, 2025
PubMed
概括

药物诱导的异常性肝损伤 (iDILI) 查需要更好的生物标志物. 新的生物标志物应该关注免疫反应,而不是直接的药物毒性,以提高药物开发安全性.

关键词:
胆盐出口可以出胆盐.细胞毒性T细胞的发生.细胞外囊泡中的细胞外囊泡.奇特的同步药物反应.奇特的药物诱导性肝损伤.天生的免疫反应.线粒体损伤造成的线粒体损伤.反应性代谢物是反应性代谢物.

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