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基于不同的攻击方法,探索金色仓鼠中JN.1的致病性和传播特征

Ruixue Liu¹, Fang Song¹, Li Sun¹

¹College of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, China; Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.

|April 20, 2025

概括

这种COVID-19 JN.1变种在子中引起疾病,但病毒载量和传染能力低于像XBB EG.5.1.1.这样的旧株,比XBB EG.5.1.1.更低. 鼻内感染导致更快的复制,但JN.1的适应能力和病原性似乎总体较差.

科学领域:

病毒学病毒学
传染性疾病传染性疾病
动物模型动物模型

背景情况:

COVID-19 JN.1 变种在2023年底迅速成为全球主导.
了解JN.1在动物模型中的特征对于评估其公共卫生影响至关重要.
以前的XBB EG.5.1等变种提供了对病原性和传染性的比较基线.

研究的目的:

在金色仓鼠模型中研究JN.1变种的致病性和传染性.
为了比较JN.1的特征与其父系菌株,BA.2和XBB EG.5.1.1.的特征.
评估不同注射途径 (鼻内 vs 胃内) 对JN.1感染的影响.

主要方法:

黄金仓鼠被用JN.1变种注射了鼻内和胃内.
评估了病毒载量,病毒标位,体重变化和组织病理学变化.
进行了直接传播研究和体内适应性评估.
分析了血液学数据,并比较了接种方法.

主要成果:

感染JN.1导致体重减轻,可检测的病毒载荷,以及对子的病理学变化.
与胃内接种相比,鼻内接种导致病毒复制速度更快.
与BA.2和XBB EG.5.1.1.相比,JN.1的病毒载量和标位显著低于BA.2和XBB EG.5.1.1.
JN.1的直接传输需要至少24小时,而XBB EG.5.1的直接传输需要6小时.
XBB EG.5.1在体内表现出比JN.1更大的适应性优势.

结论:

尽管JN.1变种占主导地位,但与XBB EG.5.1.1.相比,它的致病性和传染性降低了.
感染途径显著影响病毒复制动态.
JN.1在体内具有较弱的适应性和传染性,这表明它可能比以前占主导地位的菌株对公共卫生的威胁不那么严重.

关键词:

攻击方法攻击方法在 JN.1 里面,你会看到 JN.1 .致病性致病性致病性这就是SARS-CoV-2病毒.传输传输传输传输

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