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Updated: Jun 14, 2025

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
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A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies

Published on: November 7, 2015

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瘤及其微环境:从儿科大脑病理学中学习

Ruth Nussinov1, Bengi Ruken Yavuz2, Hyunbum Jang3

  • 1Computational Structural Biology Section, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel; Cancer Innovation Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA.

Biochimica et biophysica acta. Reviews on cancer
|April 20, 2025
PubMed
概括

研究胚胎大脑发育和病理学为儿童大脑瘤提供了新的见解. 了解发育过程可以为神经发育障碍和癌症提供新的治疗策略.

关键词:
这些CAF是CAF.癌症微环境 癌症微环境表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.血统 血统 血统 血统 血统 血统 血统过度表达是一种过度表达.转录因子 转录因子瘤的攻击性 瘤的攻击性

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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