相关实验视频

Updated: May 8, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

MINT3促进了STING的激活,并促进了抗病毒免疫反应

Yue Fu¹, Caiwei Wang², Wenyue Sun²

¹Key Laboratory for Experimental Teratology of the Chinese Ministry of Education, and Key Laboratory of Infection and Immunity of Shandong Province, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; Department of Physiology & Pathophysiology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Cellular signalling

|April 20, 2025

概括

Munc18-1-相互作用蛋白3 (MINT3) 通过促进STING转位来增强cGAS-STING通路. 这促进了I型干扰素的产生,这对抗病毒免疫力至关重要,对像HSV-1这样的病毒.

科学领域:

免疫学免疫学免疫学
分子生物学分子生物学
病毒学病毒学

背景情况:

该cGAS-STING通路检测细胞质DNA,通过I型干扰素生产启动先天免疫反应.
STING转位是这个信号级联中的关键,限制速度的步骤,但其调节尚未完全理解.

研究的目的:

为了确定STING转移和功能的新型调节者.
阐明MINT3调节cGAS-STING通路的机制.

主要方法:

使用了小鼠腹膜巨细胞,人类THP-1细胞和RAW264.7细胞.
研究了MINT3在STING激活,转位和与TBK1.1相互作用中的作用.
评估MINT3对简单疹病毒-1 (HSV-1) 感染和先天抗病毒反应的影响.

主要成果:

确定MINT3作为STING信号的积极调节者,促进I型干扰素的产生.
证明MINT3与STING相互作用,增强其K63结合的多基化,并促进其戈尔吉转位.
显示的MINT3增强了STING-TBK1相互作用,增强了对HSV-1的抗病毒免疫力,并损害了病毒复制.
在HSV-1感染和ISD刺激期间观察到MINT3表达升高.

结论:

MINT3通过增强STING转位和下游信号,积极调节cGAS-STING通路.
MINT3在抗病毒免疫力中起着重要作用,特别是对HSV-1的免疫力.
MINT3代表了STING调节中的反机制和潜在的治疗点.

关键词:

干扰素是干扰素的一种.在 MINT3 中, MINT3 在 MINT3 中, MINT3 在 MINT3 中刺痛是一种刺痛.病毒感染病毒感染.

更多相关视频

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3

Published on: January 24, 2016

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1-/- Mice

Evaluation of Zika Virus-specific T-cell Responses in Immunoprivileged Organs of Infected Ifnar1^-/- Mice

Published on: October 17, 2018

相关概念视频

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

Immune Response Against Viral Pathogens

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...