通过调节血中氧化,GCH1有助于西藏人适应高海拔
Yongbo Guo1, Wangshan Zheng2, Tian Yue1
1State Key Laboratory of Genetic Resources and Evolution, and Yunnan Key Laboratory of Integrative Anthropology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Beijing 100101, China.
西藏人适应高海拔地区,GTP循环酶1 (GCH1) 的表达减少,增加氧化 (NO) 水平. 这种适应性保护心血管和肺系统免受缺氧的影响,如GCH1淘汰赛小鼠模型所示.
科学领域:
- 人体生理学 人体生理学
- 遗传学 遗传学 是一个
- 高海拔适应 高海拔适应
背景情况:
- 氧化 (NO) 对于调节血管压力和血液流动至关重要.
- 西藏人表现出一种独特的适应高度,涉及化氧化调节.
- GTP循环酶1 (GCH1) 是一个参与这种适应的候选基因.
研究的目的:
- 研究GCH1在西藏高海拔适应中的遗传和功能作用.
- 分析GCH1在西藏人的达尔文积极选择.
- 阐明降低GH1表达在缺氧下对心血管和肺系统的生理影响.
主要方法:
- 对GCH1.1进行了全面的遗传和功能分析.
- 对西藏丰富的GCH1变体及其对基因表达的影响的分析.
- 在长期低氧状态下生成和研究异合体Gch1淘汰 (Gch1+/-) 鼠标模型.
- 将Gch1+/-小鼠与野生型 (WT) 对照对NO水平,氧和,心脏缩和肺改造进行比较.
主要成果:
- 西藏丰富的GCH1变种降低了西藏血中的GCH1表达.
- 与WT小鼠相比,Gch1+/-小鼠在低氧状态下维持了较高的血液NO和氧和水平.
- 缺氧诱导的心脏缩和肺重塑在Gch1+/-小鼠中显著减弱.
- 在Gch1+/-小鼠中观察到代谢,炎症,昼夜节律,细胞外矩阵和氧化应激的适应性分子变化.
结论:
- GCH1在调节血液中NO水平方面发挥着重要作用.
- 减少GCH1表达有助于西藏人在高海拔地区的生理适应.
- 这种适应有利于心血管和肺系统,通过改善氧气供应和减少缺氧引起的损害.
更多相关视频
05:46A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
08:23Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
Published on: February 16, 2022
相关概念视频
Nitric Oxide Signaling Pathway
Factors Affecting Respiration
Physiological Control of Respiration
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Hormonal Regulation of Blood Pressure
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
Chemical Factors Affecting Respiration Centers
CO2 has a potent influence on respiration and is strictly regulated....
