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Updated: May 20, 2025

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在两名具有免疫能力的患者中,经过重组杆疫苗接种后的疫苗接种后血清阴性自身免疫脑炎

Tariq A Madani¹, Abeer A Khoja², Ahmad R Abuzinadah²

¹Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, King Abdulaziz University, and King Abdulaziz University Hospital, Jeddah, Saudi Arabia.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

|April 20, 2025

概括

两名患者在接种Shingrix®疫苗后出现了自身免疫性脑炎 (AE). 及时的免疫疗法,包括类固醇和血酶,导致这些疫苗后AE病例的恢复.

科学领域:

神经免疫学神经免疫学
疫苗学疫苗学疫苗学

背景情况:

麻疹子病毒 (Varicella Zoster Virus,简称VZV) 导致原发性麻疹和潜伏性感染,其重新激活导致疹子病毒 (HZ).
辛格里克斯 (Shingrix®) 疫苗在预防HZ方面非常有效.
虽然通常是安全的,但罕见的不良事件需要调查.

研究的目的:

在接种Shingrix®疫苗后报告两例血清阴性自身免疫脑炎 (AE).
突出疫苗后AE的临床表现和管理.

主要方法:

在Shingrix®疫苗接种后出现神经症状的两个人的案例报告.
临床评估包括神经成像和脑脊液 (CSF) 分析.
用免疫疗法治疗,包括类固醇和等离子体合成.

主要成果:

这两位患者都出现了神经症状 (混乱,幻觉等). 在第一剂Shingrix®后的两周内.
对常见脑炎原因和AE抗体的CSF和血清测试呈阴性.
积极的免疫疗法使两名患者完全康复.

结论:

自免疫性脑炎是Shingrix®疫苗接种后的潜在并发症,尽管很少见.
早期诊断和密集免疫治疗对于管理疫苗后的AE和预防严重后果至关重要.

关键词:

自身免疫性脑炎是什么?带状疹病毒 (HZ)接种疫苗后的脑炎复合性疹疫苗复合性疹疫苗血清负性脑炎是一种脑炎.辛格里克斯®疫苗的使用疫苗安全性疫苗安全性麻疹病毒 (Varicella Zoster Virus,简称VZV) 是一种流感病毒.

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