从儿科患者中分离出的尿病原体中抗生素耐药性的模式:一个多中心研究
Zeyad A Almatroudi1, Abdullah M Almazrou1, Abdullah H Aljomoai1
1From the College of Medicine (Almatroudi, Almazrou, Aljomoai, Alsulami, Alotaibi, Almutairi, Alsehli), King Saud bin Abdulaziz University for Health Sciences, from the Department of Neonatal Intensive Care (Alsehli); and from the Department of Infection Prevention and Control (El-Saed, Alshamrani), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.
Saudi medical journal
|April 20, 2025
概括
儿童尿路感染 (UTI) 的抗生素耐药性模式因性别而异. 耐多药和产生ESBL的大肠杆菌正在增加,需要针对性别进行监测,以制定有效的治疗策略.
科学领域:
- 儿童传染病 儿童传染病
- 抗微生物药物耐药性的监测监测
- 尿病原体分析分析
背景情况:
- 尿路感染 (UTI) 在儿童中很常见.
- 泌尿病原体中的抗生素耐药性构成了重大的公共卫生挑战.
- 了解耐药性模式对于有效的儿科尿路感染管理至关重要.
研究的目的:
- 为了研究小儿患者常见尿病原体的抗生素耐药性模式.
- 为了确定男性和女性儿科患者之间的耐药性差异.
- 追踪多药耐药性和ESBL产生尿路病原体的趋势.
主要方法:
- 对被诊断患有症状,社区获得的尿路感染的儿科患者的回顾性图表审查.
- 从沙特阿拉伯利雅得的三级和初级保健中心收集的数据 (2017-2022年).
- 根据标准指南进行的尿病原体鉴定和抗生素敏感性测试.
主要成果:
- 分析了610名儿科患者的数据,83.4%是女性.
- 最常见的尿病原体:大肠杆菌 (E. coli),肺炎菌 (Klebsiella pneumoniae),神奇的蛋白质.
- 大肠杆菌在女性中更为普遍 (p<0.001). 多抗药性大肠杆菌在男性中更频繁 (39.2%对23.5%,p=0.014).
结论:
- 针对儿科尿路感染的抗生素耐药性监测应根据性别进行.
- 观察到多抗药和产生ESBL的大肠杆菌分离物的增加趋势.
- 性别差异化的数据对于指导小儿尿路感染的抗菌疗法至关重要.
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