相关实验视频
Updated: May 13, 2026

12:19
Three-Dimensional 3D Tumor Spheroid Invasion Assay
Published on: May 1, 2015
57.0K
瘤球状体,瘤器官体,瘤膨胀体和瘤体:它们之间的区别是什么?
1Medical Informatics Laboratory, Yaroslav-the-Wise Novgorod State University, Veliky Novgorod, 173003, Russia. durymanov.mo@novsu.ru.
Biochemistry. Biokhimiia
|April 20, 2025
概括
三维 (3D) 细胞培养,包括球体和有机体,对于癌症研究和药物测试至关重要. 本综述澄清了这些瘤微环境模型的定义和应用.
科学领域:
- 在瘤学瘤学.
- 生物技术是生物技术.
- 细胞生物学 细胞生物学
背景情况:
- 三维 (3D) 细胞培养对于建模瘤微环境至关重要.
- 这些模型增强了对瘤生物学和个性化医学的理解.
- 常见的3D模型包括球形体,器官体,瘤扩展体和瘤体.
研究的目的:
- 为3D多细胞培养模型提供全面的概述.
- 澄清这些模型的定义,特性和应用.
- 解决目前研究中缺乏一致的定义的问题.
主要方法:
- 对3D细胞培养模型的现有研究进行文献综述和综合.
- 分析历史发展,生物特征,优势和局限性.
- 球状体,有机体,瘤扩散体和瘤体的分类和比较.
主要成果:
- 详细描述3D文化模型的历史和演变.
- 阐明每个模型类型的独特生物特征.
- 在癌症研究和药物反应分析中具体应用的摘要.
结论:
- 需要对3D文化模型进行一致的定义和明确的区分.
- 这些模型为研究瘤生物学和开发疗法提供了显著的优势.
- 进一步标准化将提高3D细胞培养在瘤学的可靠性和适用性.
相关概念视频
Tissues
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
What is Cancer?
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
What is Cancer?
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tissues
Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...

