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Updated: May 10, 2025

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
08:47

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Published on: March 6, 2019

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通过1,5-原子转移/分子间1,4-添加过程,简要合成4'-修饰型蒂米丁

Yuta Ito1, Kang Juri1, Yasufumi Fuchi1

  • 1Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Nishihama, Yamashiro-cho, Tokushima 770-8514, Japan.

Chemical & pharmaceutical bulletin
|April 20, 2025
PubMed
概括

研究人员开发了一种简洁的方法,从天然的胺中制造出4'-改性胺. 这种方法利用4'-碳基和一合成来有效修改蒂米丁核化物.

关键词:
1,5-原子转移转移的时间4′-碳基的基因是 4′-碳基.4′-修饰的蒂米丁.通过分子间的1,4-加法.氧化物 imidate 的使用.

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