相关实验视频

Updated: May 10, 2025

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Published on: August 10, 2018

针对SARM1作为一种新型的神经保护疗法,用于神经向性病毒感染

Sheng He^{1,2,3,4,5,6,7}, Yanyan Zhu^1,2,3,4,5,6, Xinyue Wang^1,2,3,4,5,6

¹Department of Laboratory Medicine, Yuebei People's Hospital, Affiliated to Shantou University Medical College, Shaoguan, 512025, China.

Journal of neuroinflammation

|April 20, 2025

概括

向SARM1通过防止轴突退化和大脑炎症来保护病毒性脑炎. 在小鼠模型中抑制SARM1改善了神经元健康和神经向病毒感染中的生存结果.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
病毒学病毒学

背景情况:

病毒性脑炎会导致严重的神经损伤和高死亡率.
缺乏有效的治疗方法,这引起了公众健康的关注.
在神经病变中,SARM1调解轴突退化和炎症.

研究的目的:

研究SARM1在病毒性脑炎发病过程中的作用.
评估SARM1抑制作为一种治疗策略.

主要方法:

已建立的病毒性脑炎小鼠模型使用JEV,HSV-1和RABV.
评估了轴突退化,线粒体功能和神经炎症.
研究了SARM1删除或抑制的影响.

主要成果:

神经型病毒激活SARM1,导致轴突退化和神经元损伤.
抑制SARM1可以保持轴突完整性和线粒体平衡.
SARM1阻断减少了神经炎症,并改善了感染小鼠的存活率.

结论:

通过SARM1介导的轴突退化和炎症加剧病毒性脑炎.
向SARM1是神经向病毒感染的一种有前途的治疗策略.

关键词:

轴突退化轴突退化大脑炎症脑部炎症神经病理学神经病理学神经型病毒的神经型病毒这就是SARM1的作用.病毒性脑炎是一种病毒性脑炎.

更多相关视频

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

Published on: May 12, 2013

相关概念视频

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...