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循环生物标志物用于预测手术后认知能力下降的冠状动脉旁路移植患者

Vitale Miceli¹, Emanuele Lo Gerfo^2,3,4, Giovanna Russelli²

¹Department of Research, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), 90127, Palermo, Italy. vmiceli@ismett.edu.

Cellular and molecular neurobiology

|April 20, 2025

概括

心脏手术后的术后认知衰退 (POCD) 与抗氧化防御的失败有关. 像HMOX1和BDNF这样的生物标志物可以预测POCD风险,帮助早期干预.

科学领域:

神经科学是一个神经科学.
心脏病学心脏病学
生物化学生物化学

背景情况:

手术后认知能力下降 (POCD) 是心脏手术,特别是冠状动脉旁路移植 (CABG) 之后的一个重大问题.
POCD与神经炎症和氧化压力有关,影响认知功能.
确定可靠的生物标志物对于早期检测和管理至关重要.

研究的目的:

研究CABG后患者的神经营养,炎症和氧化压力标志物的动态变化.
为了确定预测POCD的潜在生物标志物.
了解CABG后认知衰退的潜在机制.

主要方法:

在基线和3个月的随访期间,从CABG后的患者收集了血液样本.
研究人员分析了氧化应激调节剂 (NRF2,GST,GSS,HMOX1,CAT,HSP27,LOX-1),炎症调解剂 (IL-6,IP-10,NFκB) 和BDNF的表达水平.
认知功能使用RBANS,TMT,TIB和MMSE进行评估.

主要成果:

患有POCD的患者最初显示抗氧化基因的增加无法维持,导致HMOX1,IP-10和BDNF的减少,以及LOX-1和NFκB的增加.
非POCD患者保持高抗氧化剂和神经保护标记,表明强大的补偿反应.
在ROC分析中,HMOX1和BDNF被确定为POCD的预测因子,LOX-1和IP-10作为后续诊断标记.

结论:

POCD的特点是持续的神经保护的失败和CABG后氧化应激和炎症的解决.
HMOX1,BDNF,LOX-1和IP-10显示出POCD风险分层和诊断的生物标志物的潜力.
需要进一步的研究和基于生物标志物的查,以改善心脏手术后的认知结果.

关键词:

生物标志物生物标志物冠状动脉绕道移植冠状动脉绕道移植神经炎症是一种神经炎症.氧化应激是一种氧化应激.手术后的认知能力下降.

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