全免疫性炎症值与缺乏症风险增加之间的相关性.
1Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Scientific reports
|April 20, 2025
概括
该研究发现,血小板与淋巴细胞比率 (PIVL) 与缺乏症风险之间存在正相关性. 较高的PIVL水平表明经历缺乏症的可能性增加.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 男人的健康 男人的健康
背景情况:
- 缺乏症显著影响男性的健康和生活质量.
- 炎症与水平有关,PIVL正在成为一种新的免疫炎症生物标志物.
- PIVL和血清丸激素之间的关系在很大程度上仍未被探索.
研究的目的:
- 为了研究PIVL和血清丸激素水平之间的关联.
- 为了确定PIVL是否可以作为丸激素缺乏的预测生物标志物.
主要方法:
- 一项横截面研究分析了NHANES (2011-2016) 中7389名参与者的数据.
- 血清总丸激素通过同位素稀释液体染色学-双重质谱法测量.
- PIVL计算为 (中性细胞数 × 单细胞数 × 血小板数) / 淋巴细胞数.
- 采用加权后勤回归,顺曲线和子组分析.
主要成果:
- 在PIVL和丸激素缺乏症的风险之间观察到正相关性.
- 与最低四分位数相比,PIVL四分位数最高的参与者患缺乏症的风险增加了51% (OR=1.51,95% CI:1.18-1.95).
- 确定了一个非线性关系,PIVL的值效应为565.89.
结论:
- PIVL与丸激素缺乏症的风险增加正相关.
- PIVL可以作为一种潜在的指标来识别丸激素缺乏风险的个体.
- 需要进一步的研究来探索PIVL对男性健康的临床影响.
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