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Updated: May 10, 2025

Visualization of DNA Repair Proteins Interaction by Immunofluorescence
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Published on: June 26, 2020

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通过HDAC6,CITK调节了在DNA双链断裂点的BRCA1招募

Giorgia Iegiani1,2, Gianmarco Pallavicini1,2, Alex Pezzotta3

  • 1Neuroscience Institute Cavalieri Ottolenghi, Turin, Italy.

Cell death & disease
|April 20, 2025
PubMed
概括

激酶 (CITK) 通过确保BRCA1局部化,对DNA修复至关重要. 在CITK缺乏细胞中准HDAC6可以恢复DNA修复,并纠正斑马鱼模型中的发育缺陷.

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