探索病例选择方法对精神病学分子遗传学研究的影响
Kenneth S Kendler1,2, Henrik Ohlsson3, Jan Sundquist3,4
1Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA. Kenneth.Kendler@vcuhealth.org.
选择参与者进行遗传研究需要仔细考虑并发症诊断. 排除患有某些疾病的个体可以显著改变严重抑郁症和其他疾病的遗传风险概况.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 分子遗传学研究依赖于精确的探针选择.
- 在精神病遗传学中采样策略的实证指导是有限的.
- 了解遗传风险需要考虑复杂的诊断关系.
研究的目的:
- 检查试验和选择决策对遗传风险概况的影响.
- 为优化心理遗传研究中的采样策略提供经验数据.
- 评估审查共患病诊断和使用二次确认的效果.
主要方法:
- 利用了一大批瑞典人口队列 (1940-2003) 诊断为严重抑郁症 (MD),焦虑症 (AD),酒精使用障碍 (AUD),药物使用障碍 (DUD),双相情感障碍 (BD) 和精神分裂症 (SZ).
- 使用经过验证的家庭遗传风险评分评估遗传风险.
- 分析了审查共患病例和使用二次确认的含义.
主要成果:
- 在主要抑郁症队列中审查焦虑障碍病例大大降低了多种疾病的遗传风险.
- 除了精神分裂症病例之外,对重大抑郁症遗传风险的影响较小,焦点较小.
- 对先前的酒精或药物使用障碍的查并没有增加特定队列中的遗传风险.
- 二次确定可以增加遗传风险,但与之密切相关的疾病显示出中度,普遍的升高.
结论:
- 试验对象的选择显著影响了精神病学研究中的遗传风险概况.
- 建议在排除并发症诊断或使用二次确认时谨慎行事.
- 这些研究结果为优化基因研究中的采样策略提供了指导方针,这些研究涉及严重抑郁症,焦虑症,物质使用障碍,双相情感障碍和精神分裂症.
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