互助学习可用于可靠的生物标志物发现和疾病预测
Jin Zhang1, Yan Yang1, Muheng Shang1
1Department of Intelligent Science and Technology, Northwestern Polytechnical University, 127 Youyi Road, 710072 Shaanxi, China.
Briefings in bioinformatics
|April 21, 2025
概括
这项研究引入了一种新的方法,用于发现生物标志物和使用多个omics数据预测疾病. 该方法提高了疾病预测的准确性,并提供了对复杂的基因环境相互作用的见解.
科学领域:
- 计算生物学 计算生物学
- 遗传学 遗传学 是一个
- 生物标志物发现发现
背景情况:
- 整合多学科数据 (基因组学,环境,成像) 识别了候选生物标志物.
- 将这些生物标志物转化为临床疾病预测,特别是与像基因环境 (G×E) 这样的复杂相互作用,仍然是困难的.
- 了解疾病病因需要可解释的高阶特征相互作用.
研究的目的:
- 提出一种新的互助因果生物标志物发现和稳定疾病预测方法 (MA-CBxDP).
- 开发一个可解释的框架来提取跨模式的共同表达模式,并识别可靠的生物标志物,包括G×E.
- 通过生物标志物发现和预测之间的相互强化,增强疾病诊断和识别致病的因果关系.
主要方法:
- 设计了一个可解释的双向映射框架,并配备了一个因果特征交互模块.
- 集成了一个合作预测模块,用于准确的诊断和因果效应识别.
- 开发了一种处理高维相互作用的快速策略,扩展到全染色体设置.
主要成果:
- 在预测临床分数和疾病状态分类方面,MA-CBxDP取得了最先进的结果.
- 该方法在识别生物标记物,包括基因与环境相互作用方面表现出了极好的解释性.
- 通过对两个数据库进行三项任务的实验验证,证实了该方法的灵活性和多功能性.
结论:
- MA-CBxDP有效地整合了多omics数据,以进行可靠的生物标志物发现和疾病预测.
- 该方法通过可解释的G×E分析,为慢性疾病病因提供了新的见解.
- 该方法的计算效率和准确性凸显了其在临床环境中的实际应用性.
更多相关视频
07:41Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
8.8K
07:35A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports
Published on: October 13, 2023
1.5K
相关概念视频
Labeling DNA Probes
DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
Methods of Classification and Identification
Bacterial identification relies on a diverse array of techniques to classify and understand microorganisms, each tailored to uncover specific characteristics. Traditional morphological approaches, while still valuable, are limited for closely related or structurally simple organisms. Modern methods integrate biochemical, serological, genetic, and advanced molecular tools to achieve greater accuracy.Morphological and Biochemical TechniquesMorphological characteristics, such as cell shape and...
Modern Molecular Taxonomy
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Rapid Identification of Pathogens
MALDI-TOF MS has transformed clinical microbiology by offering a rapid and reliable method for pathogen identification. The traditional approach to microbial identification typically involves time-consuming culture techniques and biochemical tests, which can delay the initiation of appropriate antimicrobial therapy. MALDI-TOF MS avoids these delays by using characteristic ribosomal protein mass patterns of microbial cells, enabling accurate species-level identification within minutes.Principle...
Automated Microbial Diagnostics
Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
