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儿童固体器官移植患者在移植后1年内患有细菌病

Mario M Landa¹, Ayelet Rosenthal^1,2, Caitlin Naureckas Li^1,2

¹Division of Infectious Diseases, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.

Transplant infectious disease : an official journal of the Transplantation Society

|April 21, 2025

概括

儿科固体器官移植 (SOT) 后的血流感染发生在8.4%的患者中,肝移植患者的发病率更高. 识别风险因素可以改善护理和减少住院治疗.

科学领域:

儿科固体器官移植儿科固体器官移植
传染病传染病传染病
免疫性受损的宿主

背景情况:

细菌病在免疫功能低下的儿童中存在重大风险.
关于儿科固体器官移植 (SOT) 后的血流感染 (BSI) 的数据有限.

研究的目的:

确定儿童SOT接受者的BSI发生率和风险因素.
分析BSI对患者结果和医疗保健利用的影响.

主要方法:

在14年内对581名儿科SOT接受者 (心脏,肝脏,脏) 进行了回顾性审查.
血液感染 (BSI) 和相关临床数据的分析.

主要成果:

一年内BSI发生率为8.4%,在肝移植接受者中最高.
风险因素包括年龄较小,移植期较早,重复手术,以及先前存在的糖尿病/瘤.
大多数BSI发生在90天内,通常与中心线有关;凝结酶阴性葡萄球菌和肠道共生菌很常见.
BSI并没有增加死亡率,但导致更多的住院和更长的住院时间.

结论:

儿童SOT接受者经历了显著的BSI率,尽管随着时间的推移,发病率有所下降.
识别负债表风险因素对于制定有针对性的干预措施至关重要.
干预措施可能会减少小儿SOT患者的住院护理需求.

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