水果和蔬菜消费与肝硬化患者中HCC发生的关联
Florian Manneville1, Zineb Zouakia1, Séverine Donneger2
1Université Sorbonne Paris Nord and Université Paris Cité, INSERM, INRAE, CNAM, Center of Research in Epidemiology and StatisticS (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, France.
JHEP reports : innovation in hepatology
|April 21, 2025
概括
每天食用至少240克蔬菜可显著降低法国肝硬化患者肝细胞癌 (HCC) 风险65%. 需要进一步的研究来证实这些发现的水果和蔬菜摄入量和HCC预防.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
背景情况:
- 关于水果和蔬菜消费对肝硬化患者肝细胞癌 (HCC) 风险的影响的数据有限.
- 了解这种关联对于定制HCC预防策略至关重要.
研究的目的:
- 调查水果和蔬菜摄入量与法国肝硬化患者队列中HCC发病率之间的关系.
主要方法:
- 一项前性观察性研究利用了来自法国国家队列患者的数据,这些患者患有与酒精有关的或病毒性肝硬化.
- 使用经过验证的食物频率调查问卷评估水果和蔬菜的消费,并将其分析为二元暴露 (蔬菜或水果每天≥240g,组合时每天≥400g).
- 倾向性得分和波桑回归模型被用来分析与事件HCC的关联.
主要成果:
- 在179名患者中,20名患者在7.3年的中位数随访期间发展出HCC.
- 在蔬菜消费≥240g/天 (调整后RR为0.35,p=0.04) 时,观察到HCC发病率显著降低.
- 结合水果和蔬菜摄入量≥400g/天 (RR 0.49,p=0.16) 或水果摄入量≥240g/天 (RR 0.80,p=0.68) 没有发现显著的关联.
结论:
- 该研究发现,42.5%的肝硬化患者的水果和/或蔬菜消费不足.
- 每日蔬菜摄入量≥240g与65%更低的HCC风险有关.
- 建议进行更大规模的研究来验证这些发现,并探索水果和蔬菜对HCC的保护作用.
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