乙型肝炎病毒-艾滋病毒共患病率的流行率和负担:全球系统性审查和元分析
Mequanente Dagnaw1,2, Achenef Asmamaw Muche1, Bisrat Misganaw Geremew1
1Department of Epidemiology and Biostatistics, Institute of Public Health, University of Gondar, Gondar, Ethiopia.
Frontiers in public health
|April 21, 2025
概括
乙型肝炎病毒 (HBV) 和人类免疫缺陷病毒 (HIV) 的联合感染是一个重大的全球健康问题. 这次审查发现,艾滋病毒感染的成年人中HBV的患病率很高,强调需要改进查和控制计划.
科学领域:
- * 传染病 传染病
- * 肝病学 肝病学是一门学科.
- * * 公共卫生 公共卫生
背景情况:
- *乙型肝炎病毒 (HBV) 感染是一种严重的肝病.
- * 携带HBV的同时感染在患有人类免疫缺陷病毒 (HIV) 的人群中很常见,这是由于共享的传播途径.
- *抗逆转录病毒疗法 (ART) 改善了艾滋病毒患者的寿命,使病毒共感染,特别是HBV,越来越令人担忧.
研究的目的:
- * 确定在接受ART的艾滋病毒成年人中B型肝炎疾病的全球负担.
- * 为提供全球HBV-HIV联合感染的最新综合流行率.
- * 为公共卫生战略和政策制定提供信息,以预防和控制.
主要方法:
- * 在包括谷歌学者,HINARI,EMBAS,Scopus和PubMed在内的主要数据库中进行全面的文献搜索.
- * 包含了遵循Joanna Briggs研究所方法的横截面和队列研究.
- *从选定的研究中提取数据和综合证据.
主要成果:
- *共分析了18个研究组,包括71,411名HBV-HIV联合感染的成年人.
- *从横截面研究中发现,艾滋病毒感染成人的HBV总体全球患病率为10.21% (95% CI:5.06-15.36).
- *来自队列研究的患病率为11.05% (95% CI:2.78-19.32),没有观察到统计异质性 (I2=0.0%,p=0.729和I2=0.0%,p=0.818).
结论:
- *全球HBV-HIV联合感染的患病率很大,对公共健康构成重大风险.
- * 调查结果强调需要扩大预防措施,敏感查,测试和治疗方案.
- *建议包括改进当前的控制计划,并在医疗机构建立有针对性的任务小组.
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