一个巨型多囊性副甲状腺癌的正常血表现
Keito Ichinohe1,2, Takashi Nishi3, Shintaro Goto4
1Department of Endocrinology and Metabolism, Tsugaru General Hospital, Goshogawara, Aomori 037-0074, Japan.
JCEM case reports
|April 21, 2025
概括
这种案例研究突出了副甲状腺癌的突出表现,最初具有正常的水平,随后是明显的副甲状腺癌. 通过成像,病理学和免疫组织化学证实了诊断,不包括遗传变异.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 甲状腺癌是一种罕见的内分泌恶性瘤.
- 非典型的表现可以推迟诊断,影响患者的结果.
- 早期的正常血症,其次是明显的甲状腺功能障碍症是一个不寻常的临床过程.
研究的目的:
- 报告一种罕见的副甲状腺癌病例,具有非典型的临床表现.
- 为了强调正常血性副甲状腺癌所带来的诊断挑战.
- 讨论侧甲状腺损伤中瘤转变的可能性.
主要方法:
- 一个70岁的老妇人的病例报告,前部宫质量.
- 诊断工作包括成像 (CT,超声波,Tc-99m sestamibi),血清生物化学 (,TSH,PTH) 和细针吸收.
- 手术切除 (右侧甲状腺切除) 随后进行组织病理学分析和免疫组织化学 (PTH,甲状腺素-3,副纤维素).
主要成果:
- 最初的表现是一个大,囊性前性宫质量与正常的血清和略微升高的完整的副甲状腺激素 (PTH).
- 随后形成一个固体质量,PTH水平明显升高,暗示甲状腺功能障碍.
- 副甲状腺癌的病理诊断通过囊,甲状腺和静脉入侵,阳性PTH和加勒-3染色以及高线粒体指数得到证实. 偏纤维素染色不包括与*CDC73*相关的病因.
结论:
- 副甲状腺癌可以不典型地出现初始的正常血症,模仿良性疾病.
- 连续监测和全面的诊断评估对于识别恶性转变至关重要.
- 这一案例强调了在诊断发生激素特征变化的宫瘤时考虑甲状腺癌的重要性.
更多相关视频
07:12Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
3.1K
07:13Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
14.4K
相关概念视频
00:59The Parathyroid Glands
1.8K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
1.8K
00:51Synthesis and Functions of Calcitonin
1.4K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.4K
01:17Hormones and Bone Tissue
2.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.5K
01:21Skeleton and Calcium Homeostasis
4.2K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.2K
01:24Chronic Pancreatitis I: Introduction
54
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
54
01:23The Thyroid Gland
3.3K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.3K