构成性安德罗斯坦受体,肝脏病理生理学和化学污染物:当前的证据和前景
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Updated: Aug 6, 2026
08:58
Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Francesca De Battistis1, Aleksandra Buha Djordjevic2, Luciano Saso3
1Department of Food Safety, Nutrition, and Veterinary Public Health, Italian National Institute of Health, Rome, Italy.
Frontiers in endocrinology
|April 21, 2025
概括
环境污染物激活构成性安德罗斯坦受体 (CAR),通过破坏脂质代谢,促进脂肪肝疾病 (NAFLD). 需要先进的毒理学方法来评估这些CAR介导的影响.
科学领域:
- 毒理学 毒理学 毒理学
- 分子生物学分子生物学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 构成性安德罗斯坦受体 (CAR) 是一种对排毒化学物质至关重要的外传感器.
- 汽车影响代谢过程,包括脂质和葡萄糖代谢,以及细胞增殖.
- 人们越来越认识到CAR在环境污染物引起的代谢变化中的作用.
研究的目的:
- 审查环境污染物的CAR激活与肝硬化症的发展之间的关系.
- 突出CAR在调解与异生菌相关的代谢变化的作用.
主要方法:
- 在PubMed.com上进行了文献搜索.
- 研究包括了体外和体内模型,分析了CAR-污染物和CAR-肝硬化症的关系.
主要成果:
- 像PFOA,Zearalenone,PCB和propiconazole这样的污染物会激活CAR,通过改变脂质生成,脂肪酸氧化和脂质吸收促进脂质化.
- 间接的CAR激活,特别是PFOA,有助于肝毒性,并与非酒精性脂肪肝炎 (NASH) 和非酒精性脂肪肝疾病 (NAFLD) 相关.
- 汽车激活与肝细胞缩和亡有关.
结论:
- 内分泌干扰剂,特别是农药,通过CAR调节的途径显著促进NAFLD的病原性.
- 现代毒理学工具如NAM,AOP和IATA对于理解CAR介导作用至关重要.
- 需要加强监管框架,以解决CAR在污染物引起的肝病中的作用.
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