在多囊性卵巢综合征中阻塞性睡眠呼吸暂停综合征:系统性审查和元分析
Nur K Abdul Jafar1, Afra Al Balushi2, Anuradhaa Subramanian3
1Monash Centre for Health Research and Implementation, Monash University, Clayton, VIC, Australia.
Frontiers in endocrinology
|April 21, 2025
概括
阻塞性睡眠呼吸暂停综合征 (OSAS) 在患有多囊性卵巢综合征 (PCOS) 的女性中明显更为普遍,随着症状的严重程度而增加的风险. 在PCOS患者中早期发现和治疗OSAS可能是有益的.
科学领域:
- 内分泌学和新陈代谢学
- 睡眠医学 睡眠医学
- 生殖健康 生殖健康
背景情况:
- 多囊性卵巢综合征 (PCOS) 经常与阻塞性睡眠呼吸暂停综合征 (OSAS) 相关.
- 对于OSAS对PCOS症状概况的具体影响仍然不完全理解.
- 这一系统性审查和元分析为2023年国际基于证据的PCOS指南提供了信息.
研究的目的:
- 评估PCOS和没有PCOS的女性OSAS的患病率.
- 为了评估OSAS和PCOS相关症状之间的关联.
- 为2023年国际基于证据的PCOS指南提供证据.
主要方法:
- 在多个数据库 (MEDLINE,Embase等) 进行系统的文献搜索. 在2024年5月16日之前.
- 随机效应元分析,比较PCOS和非PCOS组之间的OSAS流行率和症状.
- 根据BMI,年龄,PCOS标准和种族进行子组分析;使用GRADE评估的偏差风险和证据确定性.
主要成果:
- 在PCOS群体中,OSAS的综合患病率为37.0%,而非PCOS群体中为6.0%.
- 经过PCOS组表现出明显更高的复合OSAS风险 (OR:9.52) 和症状严重程度的风险增加.
- 在PCOS人口中的超重/肥胖,成年人和白人族群中观察到更高的OSAS风险.
结论:
- 与对照组相比,PCOS女性的OSAS患病率明显高于PCOS女性.
- 随着PCOS症状严重程度的增加,OSAS的风险会升级.
- 针对性地识别和管理PCOS患者的OSAS,特别是在特定的人口群体中,可能具有临床价值.
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