血清水平与糖尿病视网膜病变的相关性:NHANES 2011-2016年
Xi Chen1, Mei Sun1, Zhenzhen Gu1
1Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Frontiers in medicine
|April 21, 2025
概括
血清水平显示了与糖尿病视网膜病变 (DR) 的U形关联. 最佳的摄入量可能会降低DR风险,而低水平和高水平都与发病率增加有关.
科学领域:
- 内分泌学 在内分泌学.
- 眼科医生 眼科 眼科
- 营养科学 营养科学
背景情况:
- 已经确立了血清与一般健康结果之间的联系.
- 有限的研究已经探索了血清水平和糖尿病视网膜病变 (DR) 之间的特定关联.
- 和DR之间的确切关系尚不清楚.
研究的目的:
- 调查血清水平与糖尿病视网膜病变的发生率之间的联系.
- 澄清在DR的发展中的作用.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) (2011-2016) 的645名成年人的数据分析.
- 使用二进制物流回归来评估关联.
- 通过子组分析,平滑曲线拟合和倾向得分权重进行进一步调查.
主要成果:
- 多变量分析显示,血清和DR概率之间没有显著的线性关联 (p > 0.05).
- 分段回归发现了一个值效应:在含量为106.8μg/L (OR = 0.88,p = 0.0107) 的情况下,DR风险显著降低.
结论:
- 血清和DR发生率之间的关系遵循U形曲线.
- 血清水平低于最佳和过高都与DR的发病率增加有关.
- 保持水平在最佳范围内可能对减轻DR风险至关重要.
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